News - Hospital del Mar News Houdini 2 (http://houdini.antaviana.cat/) https://www.hospitaldelmar.cat/en/noticies A new strategy against pancreatic cancer attacks tumour cells and activates the immune system A study in mice by the Hospital del Mar Research Institute and the IIBB-CSIC, published in Science Advances, identifies inhibition of the PARP2 protein as a therapeutic target for treating pancreatic cancer, the third leading cause of cancer death worldwide.

The study analyses the role of this protein in tumour development and protection, and describes how its elimination leads to tumour cell death and activation of the immune System.

Specifically blocking this protein may be a useful strategy for treating a large number of patients with pancreatic cancer and could even be applicable to other types of tumours.

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Tue, 16 Jun 2026 15:29:45 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=163 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=163 0
A new pathway for developing cancer drugs discovered An international study involving researchers from the Hospital del Mar Research Institute reveals a key interaction between two proteins that are fundamental in tumour development.

To achieve this, molecular modelling and artificial intelligence techniques were used, revealing for the first time a new structural model that describes a previously unknown cell-signalling mechanism.

The research opens the door to designing drugs that act on the interaction between the two proteins, thereby improving current cancer treatments.

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Mon, 18 May 2026 09:49:30 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=162 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=162 0
A new study names part of the human genome An international study published in the journal Nature has designated a subset of the so-called dark proteins - proteins with no known function - as peptideins. Characterising them opens the door to studying them and analysing their functions.

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Fri, 15 May 2026 11:01:22 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=161 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=161 0
The way we remember is the basis of human intelligence In an article published in the journal Neuron, Dr. Rodrigo Quian Quiroga proposes that the way we organize our memories constitutes the mechanism that gives rise to human intelligence.

The human brain generates memories from the representation of the stimuli it receives, endowing them with meaning. This is a mechanism of abstraction that does not merely store information.

Published scientific evidence indicates that this mechanism is not found in other animal species, suggesting that it is a key element in the construction of our intelligence.

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Mon, 11 May 2026 09:28:30 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=160 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=160 0
Discovered one of the possible mechanisms regulating tolerance to allergens An international collaborative study, published in the Journal of Experimental Medicine, highlights the role of immunoglobulin D (IgD) in the processes involved in generating tolerance to antigens and bacteria that live in our body.

The study characterizes, for the first time, the cells that produce these antibodies and identifies their point of origin in the tonsils.

These results open the door to the possibility of developing drugs and vaccines focused on this type of antibody, both for the treatment of allergies and other diseases linked to inflammation.

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Thu, 07 May 2026 09:47:55 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=159 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=159 0
New biomarker to determine whether immunotherapy may work in people with colon and rectal cancer At present, only around 5% of patients with colon cancer are candidates for immunotherapy. This new biomarker could make it possible to determine more accurately which individuals may receive this treatment with a likelihood of success and expand the number of patients who could benefit from it.

The study, led by the Hospital del Mar Research Institute and IRB Barcelona, shows that the determination of this protein, CTHRC1, can be used to assess patient prognosis. At the same time, it opens up new avenues to approach this type of tumour.

The research team has demonstrated that this biomarker can be detected using routine diagnostic tests in the clinical practice of any Pathology service.

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Mon, 13 Apr 2026 08:39:03 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=158 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=158 0
Being physically fit helps prevent diseases A new study by the Hospital del Mar Research Institute and Universitat Ramon Llull establishes for the first time a direct link between good physical fitness and a reduced risk of suffering from more than thirty diseases.

The study, published in Medicine & Science in Sports & Exercise, identifies a causal relationship between a greater genetic predisposition for adequate cardiorespiratory capacity and a lower risk of developing these conditions.

The results suggest that increasing aerobic activity may provide protection against various cardiovascular, inflammatory, and other diseases.

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Tue, 07 Apr 2026 08:27:09 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=157 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=157 0
Researchers identify a key mechanism that promotes colorectal cancer metastasis The absence of a protein, the kinase IKKα, enables tumor cells to cluster and survive during dissemination.

The findings, published in Nature Communications, open the door to new prognostic markers and potential therapeutic strategies.

Targeting tumor cell adhesion impairs their ability to migrate and form metastases. The study was conducted using a preclinical mouse model.

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Wed, 11 Mar 2026 12:44:58 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=156 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=156 0
Reduced working hours benefit health, but may increase gender differences According to a study by the Hospital del Mar Research Institute, Pompeu Fabra University, Sant Joan de Deu Research Institute and Sant Joan de Déu Health Park, working fewer hours while maintaining the same salary has a positive effect on physical and mental health and work-life balance.

However, it also finds that, in the experiences evaluated, the measure may increase the unequal distribution of roles between women and men. It notes that women devote more time to caregiving and domestic work, while men spend more on leisure.

The researchers conducted a systematic review of the scientific evidence surrounding this type of measure. They highlight that any initiative in this field must also include an analysis of other working conditions that may have an impact on health.

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Tue, 03 Mar 2026 12:39:34 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=155 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=155 0
A large-scale study analyzes the evolution of the most common cancers in Europe A European macro-study, published in The Lancet Regional Health-Europe, analyzes disease trajectories, associated conditions, and survival among people with cancer. Hospital del Mar and the Hospital del Mar Research Institute took part in the research, which evaluates real-world clinical data from a cohort of more than 1.7 million patients from eight European countries.

The most frequent cancers in Europe are breast, prostate, colorectal, and lung cancer. The highest survival rates a re seen in breast and prostate cancer, while pancreatic cancer has the poorest prognosis.

Databases from Spain, Estonia, and Switzerland show the best survival rates.

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Tue, 17 Feb 2026 10:35:29 +0000 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=154 https://www.hospitaldelmar.cat/en/noticies/view.php?ID=154 0